First report of the oncolytic effect of EHV-1 on the non-small lung cancer – in vitro studies

Authors

  • M. Chodkowski Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland; Laboratory of Nanobiology and Biomaterials, Military Institute of Hygiene and Epidemiology, Kozielska 4 Warsaw, Poland
  • A. Slonska Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland
  • M. Bartak Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland
  • M.W. Banbura Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland
  • J. Cymerys Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland

DOI:

https://doi.org/10.24425/pjvs.2021.139986

Abstract

In recent years there have been a growing number of reports on applying viruses in oncological treatment. In the present study, we demonstrated for the first time that animal virus EHV-1 productively replicates in the human adenocarcinoma cell line (A549) without the need for adaptation. Real-time PCR analysis and mmunofluorescence assay showed that EHV-1 could infect and causes lysis of human lung cancer cells. According to our results, we can assume that EHV-1 has oncolytic potential.

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Published

2021-12-30

How to Cite

Chodkowski, M., et al. “First Report of the Oncolytic Effect of EHV-1 on the Non-Small Lung Cancer – in Vitro Studies”. Polish Journal of Veterinary Sciences, vol. 24, no. 4, Dec. 2021, pp. 607-10, doi:10.24425/pjvs.2021.139986.

Issue

Vol. 24 No. 4 (2021)

Section

Article