Effect of alkaloid berberine on the susceptibility of nontuberculous mycobacteria to antibiotics

Authors

  • K. Puk Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland
  • L. Guz Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland

DOI:

https://doi.org/10.24425/pjvs.2022.142034

Abstract

Nontuberculous mycobacteria (NTM) have recently emerged as important bacterial pathogens of both animals and humans. In this study, we aimed to evaluate the effect of a combination of ten antibiotics with an inhibitor of efflux pumps (EPI), i.e. berberine (BER), against 6 strains of NTM. Our results showed that the BER potentiated the anti-mycobacterial activities of the antibiotics. Overall, our findings show the importance of BER in increasing the efficacy of antibiotics in NTM.

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Published

2022-09-30

How to Cite

Puk, K., and L. Guz. “Effect of Alkaloid Berberine on the Susceptibility of Nontuberculous Mycobacteria to Antibiotics”. Polish Journal of Veterinary Sciences, vol. 25, no. 3, Sept. 2022, pp. 479-81, doi:10.24425/pjvs.2022.142034.

Issue

Vol. 25 No. 3 (2022)

Section

Article