Berberine enhances the antibacterial activity of thymoquinone, carvacrol and thymol against multi-drug resistant nontuberculous mycobacteria

Authors

  • K. Puk Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033 Lublin, Poland
  • L. Guz Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033 Lublin, Poland
  • A. Pastuszka Department of Biology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-033 Lublin, Poland

DOI:

https://doi.org/10.24425/pjvs.2024.151738

Abstract

The aim of this study was to investigate the activity of thymoquinone (TQ), carvacrol (CAR) and thymol (TYM) against multi-drug resistant nontuberculous mycobacteria (MDR-NTM), alone and in combination with berberine (BER). Antimicrobial activity was first evaluated at concentrations from 8 to 512 μg/mL. Each of the compounds tested exhibited good activity against nontuberculous mycobacteria (NTM) isolated from fish, with MIC values of 32-128 μg/mL. In this study, we have shown for the first time the synergistic efficacy of BER with CAR, TYM or TQ against NTM strains. Thus, the combination of these compounds with BER seems to be a new approach for combating MDR-NTM strains.

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Published

2024-09-30

How to Cite

Puk, K., et al. “Berberine Enhances the Antibacterial Activity of Thymoquinone, Carvacrol and Thymol Against Multi-Drug Resistant Nontuberculous Mycobacteria”. Polish Journal of Veterinary Sciences, vol. 27, no. 3, Sept. 2024, pp. 469-73, doi:10.24425/pjvs.2024.151738.

Issue

Vol. 27 No. 3 (2024)

Section

Article