Protective effect of mannose oligosaccharides on cadmium-induced hepatic oxidative damage in rats

Authors

  • E. Duan College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • W. Gao College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • C. Liu College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • J. Wang College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • J. Wang College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • L. Su College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • H. Qiao College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • P. Wang College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • J. Huang College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China
  • L. Gan College of Biological Engineering, Henan University of Technology, 100 Lianhua Street, Hi-tech Zone, Zhengzhou 450001, Henan, China

DOI:

https://doi.org/10.24425/pjvs.2025.154952

Abstract

The objective of this study was to investigate the effect of mannose oligosaccharides (MOS) against cadmium (Cd)-induced hepatic oxidative damage and analyze its underlying antioxidant mechanism. Thirty male Sprague-Dawley (SD) rats were randomly divided into five groups: control group and four others treated with cadmium chloride (CdCl2)(2 mg/kg body weight (b.w.)) and different MOS levels at 0, 100, 300, 500 mg/kg b.w.. The results demonstrated that administration of MOS at a dose of 500 mg/kg significantly reduced Cd-induced oxidative damage in rat livers. This was evidenced by an increase in body weight gain (BWG) and thymus index. Addtionally, liver superoxide dismutase (SOD), catalase (CAT) and total antioxidant capacity (T-AOC) activities were significantly improved compared to the group exposed to Cd alone. Conversely, MOS resulted in significant reductions in the liver index, liver malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione (GSH), and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels Morphological analysis showed that MOS ameliorated Cd-induced histopathology of the rat liver. Notably, Nrf2 gene expression levels increased, while heme oxygenase 1 (HO-1) and quinone xidoreductase 1 (NQO1) mRNA levels decreased in the MOS group. In conclusion, MOS effectively attenuate Cd-induced oxidative damage in rat liver and the Nrf2 signaling pathway is involved in this process. This study provides valuable insights for the implementation of MOS applications in livestock and poultry production.

Downloads

Published

2025-06-30

How to Cite

Duan, E., et al. “Protective Effect of Mannose Oligosaccharides on Cadmium-Induced Hepatic Oxidative Damage in Rats”. Polish Journal of Veterinary Sciences, vol. 28, no. 2, June 2025, pp. 311-20, doi:10.24425/pjvs.2025.154952.

Issue

Vol. 28 No. 2 (2025)

Section

Article