Iort aqure in flash mode: dosimetric control in breast cancer cell in vitro experiments
DOI:
https://doi.org/10.24425/mms.2025.155811Abstract
Ultra-high-dose rate (FLASH) radiotherapy is a promising cancer treatment method in which high doses of radiation are delivered in a very short time, minimising damage to healthy tissue while effectively targeting tumour cells. In this study, the IORT AQURE accelerator was used in FLASH mode to irradiate breast cancer cells. Dosimetric verification was carried out to confirm the quality of the beam used in the study and to control the doses (5, 10, and 15 Gy) administered to the cells. Gamma index analysis confirmed the accuracy of dose distribution, with results exceeding 96% for all cell samples. Radiobiological testing demonstrated a 90% reduction in the viability of HCC38 breast cancer cells at a dose of 15 Gy. These results validate the film dosimetry for controlling the beam and doses and the use of the AQURE accelerator in the FLASH mode for preclinical research and confirm its potential for future preclinical studies and clinical applications.References
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